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Clinical Trials & Research

Working Towards a Future Free from HypoPARA

The HypoPARAthyroidism Association has always advocated for participation in patient studies and other investigative medical initiatives. Medical research and patient participation is necessary if medical science is to be advanced, and patient’s quality of life improved.

Types of Clinical Trials

Some trials are drug trials which mean you will receive medication as part of the trial. Some are natural history or other forms of investigational studies that do not involve any medication. There are also trials like the one below that is for allotransplantation (a surgical procedure) or ones that are diagnostic in nature. Always make sure to understand what type of trial you are signing up for as well as discuss the trial with your individual doctor.

If you have questions regarding what it is like to participate in a clinical trial please reach out to the association with your specific question(s). Several of our board members have participated in trials.

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Current Clinical Trials

There are several clinical trials taking place on hypoPARAthyroidism at this time. You can always check for updates online at or for the complete list of current and upcoming research protocols.


Parathyroid Allotransplantation in Medically Refractory HypoPARAthyroidism (PATH)

This study is to have parathyroid tissue transplanted.


Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1 (CALIBRATE)

This randomized Phase 3 study, sponsored by Calcilytix Therapeutics, Inc. (a BridgeBio company), will be conducted in adolescents and adults with ADH1 who have not previously used Encaleret.

Learn more about CALIBRATE

Expanded Access Program of Palopegteriparatide in Patients With Hypoparathyroidism

This study, sponsored by Ascendis Pharma, is an expanded access program (EAP) for eligible participants who previously received PTH treatment and who are ineligible for an ongoing TransCon PTH clinical trial.


CLARIFY: ADH1 and ADH2 Disease Monitoring Study (DMS)

Sponsored by Calcilytix Therapeutics, Inc. (a BridgeBio company), this disease monitoring study (DMS) includes adult and pediatric participants with ADH1 or ADH2. The study is designed to gain a better understanding of the standard of care practices and treatments in a real-world setting.

Learn more about Clarify

Natural History Study – SHINE

A natural history study is a preplanned observational study intended to track the course of the disease. Its purpose is to identify demographic, genetic, environmental, and other variables (e.g., treatment modalities, concomitant medications) that correlate with the disease’s development and outcomes. Natural history studies are likely to include patients receiving the current standard of care and/or emergent care, which may alter some manifestations of the disease.

LEARN MORE about Shine

MBX 2109

This study is to investigate the safety, pharmacokinetics, and efficacy of MBX 2109 administered once weekly to patients with hypoparathyroidism. Given MBX 2109 is intended as a PTH replacement hormone to demonstrate that MBX 2109 can maintain serum calcium within a normal range without the need for active vitamin D and therapeutic calcium supplements.

Clinical Trial Link

Finding Clinical Trials

You can always check for updates at website or CenterWatch for the complete list of current and upcoming research protocols. is a database of privately and publicly funded clinical studies conducted around the world. It is a resource provided by the U.S. National Library of Medicine. 



CenterWatch first launched the Clinical Trials Listing Service in 1994 to assist patients in finding and volunteering for clinical trials. Today, CenterWatch has the largest online listing of actively recruiting clinical trials and is one of the most trusted resources for patients interested in clinical trial participation receiving more than 1.5 million unique patients visitors annually.

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Additional Resources